Journal
SCIENCE
Volume 297, Issue 5588, Pages 1867-1870Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1073514
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- NHLBI NIH HHS [HL60137] Funding Source: Medline
- NIAID NIH HHS [AI44219, AI44759] Funding Source: Medline
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Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123(+) DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
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