Journal
BRAIN RESEARCH
Volume 949, Issue 1-2, Pages 42-50Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)02963-3
Keywords
angiotensin-converting enzyme inhibitor; captopril; drinking; organum vasculosum laminae terminalis; sodium appetite; sodium depletion; subfornical organ
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Funding
- NINDS NIH HHS [NS-22274] Funding Source: Medline
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Two circumventricular organs, the subfornical organ (SFO) and organum vasculosum laminae terminalis (OVLT), may mediate salt appetite in response to acute intravenous infusions of angiotensin (ANG) II. Fluid intakes and mean arterial pressures were measured in rats with sham lesions or electrolytic lesions of the SFO or OVLT during an intravenous infusion of 30 ng/min ANG H. Beginning 21 h before the 90-min infusion, the rats were depleted of sodium with furosemide and given a total of 300 mg/kg captopril in 75 ml/kg water in three spaced gavages to block the usual salt appetite and to hydrate the rats. No other food or fluids were available for ingestion. Sham-lesioned rats drank 9.3+/-1.2 nil if 0.3 M NaCl alone was available and drank 8.9+/-1.6 ml of saline and 3.7+/-1.6 nil of water if both were available. Either SFO or OVLT lesions reduced the intakes of saline to <5 ml in both conditions and of water to <1 nil. Mean arterial pressure did not differ among the group, and was maintained above 100 mmHg after the depletion and captopril treatments because of the large doses of water. Thus, a full expression of salt appetite in response to an acute intravenous infusion of ANG 11 requires the integrity of both the SFO and OVLT. (C) 2002 Elsevier Science B.V. All rights reserved.
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