Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 451, Issue 2, Pages 161-164Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(02)02301-4
Keywords
patch-clamp, whole-cell; adenosine A(2A) receptor; NMDA receptor; striatum
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The effects of the adenosine A(2A) receptor agonist 2-p-(2-carboxyethyl)phenethyl-amino-5'-N-ethylcarboxamidoadenosine (CGS 21680) on currents mediated by excitatory amino acid receptors were examined in rat striatal brain slices. In a Mg2+-free superfusion medium, CGS 21680 decreased the amplitude of excitatory postsynaptic currents (EPSCs) in about 70% of striatal neurons. The inhibitory effect of CGS 21680 disappeared both in the presence of the adenosine A(2A) receptor antagonist 8-(3-chlorostyryl) caffeine and the NMDA receptor antagonist 2-amino-5-phosphonopentanoic acid (AP-5). NMDA-induced currents were also depressed by CGS 21680 in a subset of striatal cells, whereas alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-induced currents were not affected. The results suggest that adenosine A(2A) receptor agonists inhibit the NMDA component of the EPSC. (C) 2002 Elsevier Science B.V. All rights reserved.
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