Journal
BRAIN RESEARCH
Volume 949, Issue 1-2, Pages 209-212Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)03157-8
Keywords
sleep; GABA; GAD; cytokines
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Funding
- NIMH NIH HHS [MH60308] Funding Source: Medline
- NINDS NIH HHS [NS27250, NS25378] Funding Source: Medline
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GHRH and IL1beta regulate steep via the hypothalamus. However, actions of these substances on neurons are poorly understood. In this study, we found both GHRH (100 nM) and IL1beta (1.2 pM) acutely increased cytosolic Ca2+ in 7.6 and 4.0% of cultured hypothalamic neurons tested, respectively, and 1.2% of neurons responded to both. The neurons that responded were mostly GABAergic (96, 81, and 100%, for GHRH, IL1beta, and dual-responsive neurons, respectively). (C) 2002 Elsevier Science B.V. All rights reserved.
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