Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 33, Issue 6, Pages 755-764Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0891-5849(02)00901-2
Keywords
nitric oxide; mitochondria; signaling; cytochrome; NOS; apoptosis; free radicals
Funding
- NHLBI NIH HHS [HL58031] Funding Source: Medline
- NIAAA NIH HHS [AA12613] Funding Source: Medline
- NIEHS NIH HHS [ES10167] Funding Source: Medline
Ask authors/readers for more resources
The functional role of mitochondria in cell physiology has previously centered around metabolism, with oxidative phosphorylation playing a pivotal role. Recently, however, this perspective has changed significantly with the realization that mitochondria are active participants in signal transduction pathways, not simply the passive recipients of injunctions from the rest of the cell. In this review the emerging role of the mitochondrion in cell signaling is discussed in the context of cytochrome c release, hydrogen peroxide formation from the respiratory chain, and the nitric oxide-cytochrome c oxidase signaling pathway. (C) 2002 Elsevier Science Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available