Journal
JOURNAL OF IMMUNOLOGY
Volume 169, Issue 6, Pages 2818-2822Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.169.6.2818
Keywords
-
Categories
Funding
- NCI NIH HHS [N01-CO-12400] Funding Source: Medline
Ask authors/readers for more resources
NK cell activity is partially controlled through interactions between killer Ig-like receptors (KIR) on NK cells and their respective HLA class I ligands. Independent segregation of HLA and KIR genes, along with KIR specificity for particular HLA allo-types, raises the possibility that any given individual may express KIR molecules for which no ligand is present. Inhibitory receptor genes KIR2DL2/3 and KIR2DL1 were present in nearly all subjects sampled in this study, whereas their respective activating homologs, KIR2DS2 and KIR2DS1, are each present in about half of the subjects. In this work we report that subjects with activating KIR2DS1 and/or KIR2DS2 genes are susceptible to developing psoriatic arthritis, but only when HLA ligands for their homologous inhibitory receptors, KIR2DL1 and KIR2DL2/3, are missing. Absence of ligands for inhibitory KIRs could potentially lower the threshold for NK (and/or 1) cell activation mediated through activating receptors, thereby contributing to pathogenesis of psoriatic arthritis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available