Journal
SYNAPSE
Volume 45, Issue 4, Pages 213-219Publisher
WILEY
DOI: 10.1002/syn.10104
Keywords
addiction; brain; forskolin; cAMP; plasticity; tetanus; induction; maintenance; excitability
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Funding
- NIDA NIH HHS [DA 14151] Funding Source: Medline
- NINDS NIH HHS [T32 NS 07491] Funding Source: Medline
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Glutamatergic transmission in the nucleus accumbens (NAc) has been shown to be important for behavioral adaptations in response to drugs of abuse. NMDA-receptor dependent long-term potentiation (LTP) of glutamatergic synaptic transmission has been hypothesized to underlie many lasting alterations in behavior. Thus, we examined LTP in NAc core and find that it is developmentally regulated. Specifically, tetanus-evoked, NMDA receptor-dependent LTP is observed in the NAc of adolescent (3-week-old) mice more frequently than in adult (6-20-week-old) mice. In contrast, cAMP-dependent enhancement of transmission is not developmentally regulated. Removal of extracellular Mg2+ restores LTP in adult NAc core, suggesting developmental regulation of induction processes rather than maintenance mechanisms. These findings are discussed in the context of behavioral changes elicited in response to drugs of abuse, which differ in adolescent vs. adult rodents and humans. (C) 2002 Wiley-Liss, Inc.
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