Journal
JOURNAL OF CELL BIOLOGY
Volume 158, Issue 6, Pages 1079-1087Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200202049
Keywords
Wnt-signaling; beta-catenin; MITF; survival; melanoma
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Funding
- NHLBI NIH HHS [T32 HL007574, HL 07574-20] Funding Source: Medline
- NIAMS NIH HHS [R01 AR043369, AR 43369] Funding Source: Medline
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The transcription factor Microphthalmia-associated transcription factor (MITF) is a lineage-determination factor, which modulates melanocyte differentiation and pigmentation. MITF was recently shown to reside downstream of the canonical Wnt pathway during melanocyte differentiation from pluripotent neural crest cells in zebrafish as well as in mammalian melanocyte lineage cells. Although expression of many melanocytic/pigmentation markers is lost in human melanoma, MITF expression remains intact, even in unpigmented tumors, suggesting a role for MITF beyond its role in differentiation. A significant fraction of primary human melanomas exhibit deregulation (via aberrant nuclear accumulation) of beta-catenin, leading us to examine its role in melanoma growth and survival. Here, we show that beta-catenin is a potent mediator of growth for melanoma cells in a manner dependent on its downstream target MITF Moreover, suppression of melanoma clonogenic growth by disruption of beta-catenin-T-cell transcription factor/ LEF is rescued by constitutive MITF This rescue occurs largely through a prosurvival mechanism. Thus, beta-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm.
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