Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 196, Issue 6, Pages 859-865Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20020781
Keywords
respiratory syncytial virus; enhanced disease; immune complexes; airway hyperresponsiveness; compliment
Categories
Ask authors/readers for more resources
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral Pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell-deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available