Journal
ORGANIC LETTERS
Volume 4, Issue 19, Pages 3231-3234Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol026438g
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- NIGMS NIH HHS [GM-45617] Funding Source: Medline
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A highly convergent total synthesis of (+)-brefeldin A that relies on a diastereoselective, beta-lactone-based cyclopentane synthesis combined with complex cross-metathesis reactions is described. The utility of beta-lactones for natural product synthesis and the versatility of cross-metathesis in this context were demonstrated, including the tolerance of an epimerizable aldehyde and a beta-lactone.
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