Journal
NEUROLOGY
Volume 59, Issue 6, Pages 944-946Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.59.6.944
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- NINDS NIH HHS [P01 NS32352-P2] Funding Source: Medline
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The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 +/- 2 vs 81 +/- 10 cells/section, p < 0.001) and laterodorsal tegmental nucleus (18 +/- 3 vs 47 +/- 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.
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