Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 50, Issue 20, Pages 5683-5685Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf020267c
Keywords
Morchella esculenta; morel; immunostimulatory polysaccharide; galactomannan; THP 1 cells; nuclear factor kappa B
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The edible mushroom Morchella esculenta is among the most highly prized and morphologically recognizable fungi in the world We describe the isolation from a polar extract of M esculenta carpophores of a high molecular weight galactomannan, about 1 0 million Da, that exhibits immunostimulatory activity At 3 0 mug/mL the galactomannan polysaccharide increased NF-kappa B directed luciferase expression in THIP 1 human monocytic cells to levels 50% of those achieved by maximal activating concentration (10 mug/mL) of lipopolysaccharide This galactomannan comprises about 2 0% of the dry fungal material weight and its glycosyl components include mannose (62 9%) and galactose (20 0%).
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