Journal
VETERINARY PARASITOLOGY
Volume 108, Issue 3, Pages 195-205Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0304-4017(02)00195-4
Keywords
cattle-protozoa; control methods-protozoa; Theileria parva schizonts; East Coast fever; parvaquone; frusemide; advanced-stage treatment; pulmonary signs
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Comparative studies of the efficacy of parvaquone (Parvexon(R)) and parvaquone-plus-frusemide (Fruvexon(R)) Bimeda Chemicals, Ireland, were done on 60 naturally infected cases of East Coast fever (ECF; Theileria parva infection in cattle). Small-scale dairy farmers in the peri-urban of Dar Es salaam city reported ECF-suspected cases from March to mid-October 2001 and were treated with the two drugs alternately, as were diagnosed positive for ECF. Four sub-groups of 15 cattle each (early stage, 15; advanced stage, 15) were treated with parvaquone and parvaquone-plus-frusemide. Twenty-eight out of 30 (93.3%) cattle treated with parvaquone-plus-frusemide were cured, so do 24 out of 30 (80.0%) cattle treated with parvaquone without frusemide. Early diagnosis and prompt management of pulmonary signs, which accounted for 30.0% of total ECF cases is advised in order to improve cure rates. Unlike parvaquone without frusemide (Parvexon), parvaquone-plus-frusemide (Fruvexon) proved useful in the management of pulmonary signs, hence, a drug of choice in the treatment of ECF cases that are accompanied by or are likely to manifest pulmonary signs. (C) 2002 Elsevier Science B.V. All rights reserved.
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