Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 195, Issue 1-2, Pages 1-26Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0303-7207(02)00222-8
Keywords
selective uptake pathway; steroidogenesis; cholesteryl esters; steroids; SR-B1; lipoproteins
Categories
Funding
- NHLBI NIH HHS [HL33881] Funding Source: Medline
- NIDDK NIH HHS [DK56339] Funding Source: Medline
Ask authors/readers for more resources
The steroidogenic tissues have a special requirement for cholesterol, which is used as a substrate for steroid hormone biosynthesis. In many species this cholesterol is obtained from plasma lipoproteins by a unique pathway in which circulating lipoproteins bind to the surface of the steroidogenic cells and contribute their cholesteryl esters to the cells by a 'selective' process in which the whole lipoprotein particle does not enter the cell. This review describes the lipoprotein selective cholesteryl ester uptake process and its specific partnership with the HDL receptor, scavenger receptor class BI (SR-BI). It describes the characteristics of the selective pathway, and the molecular properties, localization, regulation, anchoring sites and potential mechanisms of action of SR-BI in facilitating cholesteryl ester uptake by steroidogenic cells. Published by Elsevier Science Ireland Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available