Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 6, Issue 5, Pages 676-681Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S1367-5931(02)00370-8
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Funding
- NIGMS NIH HHS [GM 58008] Funding Source: Medline
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MALDI MS imaging mass spectrometry can be used to map the distribution of targeted compounds in tissue sections with a spatial resolution currently of about 50 mum, providing important molecular information in many areas of biological research. After matrix application, a raster of a section by the laser beam yields ions from compounds in a tissue mass-to-charge range from 1000 to over 100 000. Two-dimensional intensity maps can then be reconstructed to provide specific molecular images of a tissue.
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