Journal
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume 17, Issue 5, Pages 581-588Publisher
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2002.17.5.581
Keywords
HIF1alpha; Arnt; cell hypoxia
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Hypoxia-inducible factor-1 (HIF-1) is composed of HIF-1 alpha and HIF-1 beta, and is a master regulator of oxygen homeostasis, playing critical roles in physiological and pathological processes. Normally, the formation and transcriptional activity of HIF-1 depend on the amount of HIF-1 alpha, and the expression of HIF-1 alpha is tightly controlled by the cellular oxygen tension. Recent progress in the study of its regulation mechanism provided clues as to how HIF-1 alpha is regulated by oxygen. It appears that HIF-1 alpha is not regulated only by the oxygen tension, but also by various other stimuli, such as transition metals, nitric oxide, reactive oxygen species, growth factors, and mechanical stresses. In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1alpha, and the respective physiological and pathological meanings.
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