Journal
DIABETOLOGIA
Volume 45, Issue 10, Pages 1468-1474Publisher
SPRINGER
DOI: 10.1007/s00125-002-0937-z
Keywords
Type I diabetes; autoimmune disease; vaccination; HSP60; peptide p277; immune modulation; hypothesis driven research; immunological homunculus
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The autoimmune process that produces Type I (insulin-dependent) diabetes mellitus seems to respond favourably to therapeutic vaccination with a peptide of the 60 kDa heat shock protein. This article is a personal review of the observations and the thinking that gave rise to the idea of therapeutic peptide vaccination. The rationale for vaccination therapy is compared to other approaches aimed at specific immunological treatment for autoimmune disease.
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