Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 14, Issue 5, Pages 594-602Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(02)00368-X
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Funding
- NCI NIH HHS [K01CA87652] Funding Source: Medline
- NHLBI NIH HHS [R01 HL/HD64597] Funding Source: Medline
- NIDCR NIH HHS [P60 DE13958] Funding Source: Medline
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Recent advances highlight a critical role for integrin receptors for extracellular matrix in determining where in cells critical signals are transduced. Integrins are shown to activate signaling intermediates at specific surface membrane locations, to promote nuclear translocation of factors that activate gene transcription, and to recruit and augment the signaling power of receptors for growth factors.
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