Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 59, Issue 10, Pages 1658-1665Publisher
BIRKHAUSER VERLAG AG
DOI: 10.1007/PL00012493
Keywords
mitochondria; Hsp70; Fe/S center; iron; Jac 1; Ssq 1; molecular chaperone
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Funding
- NIGMS NIH HHS [GM27870] Funding Source: Medline
- PHS HHS [3P04A05023] Funding Source: Medline
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Mitochondria contain a specialized system of molecular chaperones that plays a critical role in the biogenesis of Fe/S centers. This Hsp70:J-protein system shows many similarities to the system found in bacteria, but the precise role of neither chaperone system has been defined. However, evidence to date suggests an interaction with the scaffold protein on which a transient Fe/S center is assembled, and thus implies a role in either assembly of the center or its transfer to recipient proteins.
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