Journal
IMMUNOLOGY
Volume 107, Issue 2, Pages 176-182Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2567.2002.01495.x
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CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.
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