Journal
GENE THERAPY
Volume 9, Issue 19, Pages 1271-1277Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gt.3301798
Keywords
VEGF; gene therapy; wound healing; diabetes
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Funding
- Telethon [A.061] Funding Source: Medline
- Fondazione Telethon Funding Source: Custom
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It has been previously shown that vascular endothelial growth factor (VEGF) plays a central role in promoting angiogenesis during wound repair and that healing-impaired diabetic mice show decreased VEGF expression levels. In order to Investigate the potential benefits of gene therapy with growth factors on wound repair, a replication-deficient recombinant adenovirus vector carrying the human VEGF(165) gene (AdCMV.VEGF(165)) was topically applied on excisional wounds of streptozotocin-induced diabetic mice. Treatment with AdCMV.VEGF(165) significantly accelerated wound closure when compared with AdCMV.LacZ-treated, as well as saline-treated control mice, by promoting angiogenesis at the site of injury. Our findings suggest that AdCMV.VEGF(165) may be regarded as a therapeutic tool for the treatment of diabetic ulcers.
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