Journal
SEMINARS IN CANCER BIOLOGY
Volume 12, Issue 5, Pages 389-398Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S1044-579X(02)00059-7
Keywords
epigenetics; DNA methylation; genomic imprinting
Categories
Funding
- NCI NIH HHS [R37 CA054358-12, CA65145, R37 CA054358] Funding Source: Medline
Ask authors/readers for more resources
Since the discovery of epigenetic alterations in cancer 20 years ago by Feinberg and Vogelstein, a variety of such alterations have been found, including global hypomethylation, gene hypomethylation and hypermethylation, and loss of imprinting (LOI). LOI may precede the development of cancer and may thus serve as a common marker for risk, but also as a model for understanding the developmental mechanism for normal imprinting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available