Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 110, Issue 8, Pages 1093-1103Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200215693
Keywords
-
Categories
Funding
- Medical Research Council [G108/380] Funding Source: researchfish
- Medical Research Council [G108/380] Funding Source: Medline
- Wellcome Trust [068086] Funding Source: Medline
Ask authors/readers for more resources
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence,of multiple physiological functions of this hormone in rodents. In contrast, information regarding the roles of this hormone in humans is limited. Three morbidly obese children, who were congenitally deficient in leptin, were treated with daily subcutaneous injections of recombinant human leptin for up to 4 years with sustained, beneficial effects on appetite, fat mass, hyperinsulinemia, and hyperlipidemia. Leptin therapy resulted in a rapid and sustained increase in plasma thyroid hormone levels and, through its age-dependent effects on gonadotropin secretion, facilitated appropriately timed pubertal development. Leptin deficiency was associated with reduced numbers of circulating CD4(+) T cells and impaired T cell proliferation and cytokine release, all of which were reversed by recombinant human leptin administration. The subcutaneous administration of recombinant human leptin has major and sustained beneficial effects on the multiple phenotypic abnormalities associated with congenital human leptin deficiency.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available