Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 12, Issue 5, Pages 593-598Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(02)00371-8
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Funding
- NIGMS NIH HHS [GM 61126, R01 GM061126] Funding Source: Medline
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Recent studies from several laboratories have provided evidence that cell surface complex carbohydrates play key roles in the regulation of developmentally relevant signal transduction events. The demonstration that Fringe, a known modifier of Notch function, is a fucose-specific N-acetylglucosaminyltransferase provided strong evidence that the Notch signaling pathway could be regulated by alterations of O-fucose structures. More recently, the demonstration that O-fucose modification of Cripto is essential for Nodal-dependent signaling provides further evidence of a role for glycosylation in signal transduction. These and other examples provide a new paradigm for the regulation of signal transduction events by glycosylation.
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