Journal
GLYCOBIOLOGY
Volume 12, Issue 10, Pages 127R-136RPublisher
OXFORD UNIV PRESS INC
DOI: 10.1093/glycob/cwf081
Keywords
apoptosis; galectin; glycosyltransferase; immune system; T cell
Categories
Funding
- NCI NIH HHS [CA009120] Funding Source: Medline
- NIGMS NIH HHS [GM63281, GM08042] Funding Source: Medline
Ask authors/readers for more resources
Control of cell death is critical in eukaryotic development, immune system homeostasis, and control of tumorigenesis. The galectin family of lectins is implicated in all of these processes. Other families of molecules function as death receptors or death effectors, but galectins are uniquely capable of acting both extracellularly and intracellularly to control cell death. Extracellularly, galectins cross-link glycan ligands to transduce signals that lead directly to death or that influence other signals regulating cell fate. Intracellular expression of galectins can modulate other signals controlling cell viability. Individual galectins can act on multiple cell types, and multiple galectins can act on the same cell. Understanding how galectins regulate cell viability and function will broaden our knowledge of the roles of galectins in basic biological processes and facilitate development of therapeutic applications for galectins in autoimmunity, transplant-related disease, and cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available