Journal
IMMUNOLOGY LETTERS
Volume 83, Issue 3, Pages 215-220Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-2478(02)00088-3
Keywords
immunohistochemistry; CD28/B7 family; costimulatory molecule
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PD-1 is an immunoinhibitory receptor, which belongs structurally to the CD28 family. PD-1-deficient mice show breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. We previously described expression of PD-1 on activated T and B lymphocytes and myeloid cells. However, little is known about the microanatomical distribution of PD-1 in lymphoid organs. In this study, we performed immunohistochemistry using monoclonal antibodies against human PD-1. In human tonsils, PD-1 was expressed on most of T cells and a small subset of centrocytes in the light zone of germinal centers (GCs), where clonal selection of centrocytes takes place. These results suggest that PD-1 may play an important role in GC reaction. (C) 2002 Elsevier Science B.V. All rights reserved.
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