Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 3, Issue 10, Pages 767-778Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm930
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Members of the structural maintenance of chromosomes (SMC) family share a characteristic design and configuration of protein domains that provides the molecular basis for the various functions of this family in chromosome dynamics. SMC proteins have a role in chromosome condensation, sister-chromatid cohesion, DNA repair and recombination, and gene dosage compensation, and they function in somatic and meiotic cells. As more is learned about how their unique design affects their function, a picture of a dynamic and varied protein family is emerging.
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