Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 12, Issue 5, Pages 524-533Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(02)00336-2
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During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.
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