Journal
TRENDS IN PLANT SCIENCE
Volume 7, Issue 10, Pages 425-427Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1360-1385(02)02334-8
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The isolation of over 30 plant disease-resistance genes revealed that most genes encode putatively cytoplasmic proteins with a nucleotide-binding site (NBS) and a leucine-rich repeat (LRR). However, the recent isolation of the Arabidopsis RRS1-R gene has uncovered a novel NBS-LRR subtype that harbors a C-terminal extension with a putative nuclear localization signal and a DNA-binding domain that is characteristic of the WRKY transcription factor family. This suggests that RRS1-R, unlike any other known R protein, is targeted to the nucleus to fulfill its function.
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