4.7 Article

Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 46, Issue 10, Pages 3334-3336

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.46.10.3334-3336.2002

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Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. We analyzed nine clinical isolates of linezolid-resistant enterococci and showed a clear association between the number of 23S rRNA genes containing this mutation and the level of linezolid resistance expressed.

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