Dose escalation, safety and immunogenicity study of a tetravalent meninogococcal polysaccharide diphtheria conjugate vaccine in toddlers

Two injections of tetravalent (Groups A, C, Y and W-135) meningococcal polysaccharide vaccine conjugated to diphtheria were given to 30 toddlers at dosages of 1, 4 and 10 mug/ml polysaccharide of each serogroup. Reactogenicity was acceptable at all dosages. The 4-mug/ml dose appears to be immunologically optimal.