Journal
REVISTA CLINICA ESPANOLA
Volume 202, Issue 10, Pages 543-545Publisher
EDICIONES DOYMA S/L
DOI: 10.1016/S0014-2565(02)71139-9
Keywords
HIV; hepatitis C; hiperlactacidemia; lactic acidosis; treatment; adverse effect
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The hepatitis C infection is highly prevalent among HIV-infected patients. As a direct consequence of the increased survival of these patients in the HAART era, liver disease and its long-term complications have became a genuine health problem in these patients. The treatment of chronic HCV hepatitis is associated with several secondary effects, hiperlactacidemiae/lactic acidosis is one of the most dangerous. It appears to be related with the association of ribavirin and ddl, d4T or AZT. These are three cases of hiperlactacidemiae/lactic acidosis collected during the first twelve months of treatment with pegylated interferon and ribavirin in University Hospital of Guadalajara.
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