Journal
BIOLOGICAL PSYCHIATRY
Volume 52, Issue 7, Pages 694-700Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(02)01502-0
Keywords
glucose metabolism; glutamate-glutamine cycle; glutamine synthesis; magnetic resonance spectroscopy; stable isotope labels
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Funding
- NIBIB NIH HHS [R01 EB 00315] Funding Source: Medline
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In vivo magnetic resonance spectroscopy (MRS) is a noninvasive technique for the measurement of the concentration and synthesis of metabolites in the brain. Application of the state-of-the-art in vivo C-13 anti N-15 MRS techniques to studying the synthesis of glutamate and glutamine has revealed that the glutamate-glutamine cycle between neurons and glia is a major metabolic flux, with a flux rate of 60%-80% relative to neuronal oxidative glucose metabolism in the resting human cerebral cortex. The MRS studies leading to the quantification of the glutamate-glutamine cycling flux are reviewed here. The advantages and limitations of different strategies are also discussed. (C) 2002 Society of Biological Psychiatry.
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