Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
Volume 62, Issue 1, Pages 56-72Publisher
WILEY
DOI: 10.1002/jbm.10221
Keywords
cell-surface interactions; MC3T3-E1 cells; Ti6Al4V; surface textures; laser microgrooves
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This paper presents the results of an experimental study of the interactions between MC3T3-E1 (mouse calvarian) cells and textured Ti6Al4V surfaces, including surfaces produced by laser microgrooving; blasting with alumina particles; and polishing. The multiscale interactions between MC3T3-E1 cells and these textured surfaces are studied using a combination of optical scanning transmission electron microscopy and atomic force microscopy. The potential cytotoxic effects of microchemistry on cell-surface interactions also are considered in studies of cell spreading and orientation over 9-day periods. These studies show that cells on microgrooved Ti6Al4V geometries that are 8 or 12 mum deep undergo contact guidance and limited cell spreading. Similar contact guidance is observed on the surfaces of diamond-polished surfaces on which nanoscale grooves are formed due to the scratching that occurs during polishing. In contrast, random cell orientations are observed on alumina-blasted Ti6Al4V Surfaces. The possible effects of surface topography are discussed for scar-tissue formation and improved cell-surface integration. (C) 2002 Wiley Periodicals, Inc.
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