Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 131, Issue 1-2, Pages 135-146Publisher
ELSEVIER
DOI: 10.1016/S0165-5728(02)00272-2
Keywords
Alzheimer's; factor H; heparan sulfate proteoglycan; agrin; complement receptor 3; amyloid beta
Categories
Funding
- NIA NIH HHS [AGO7367] Funding Source: Medline
- NINDS NIH HHS [NS33981] Funding Source: Medline
Ask authors/readers for more resources
Factor H, a regulatory protein of the alternative pathway of complement (APC), is present in amyloid-beta (Abeta) plaques in Alzheimer's disease (AD). Abeta plaques also contain significant amounts of heparan sulfate proteoglycans (HSPGs), such as agrin, as well as numerous activated microglia expressing increased levels complement receptor 3 (CR3). Here, we show the colocalization of each of these molecules in the AD brain and the functional capacity for these molecules to bind to one another in vitro. We propose that CR3 receptors expressed by microglia are used for ligand binding to factor H bound to HSPGs and Abeta in plaques in the AD brain. (C) 2002 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available