Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 22, Issue 10, Pages 1170-1175Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wcb.0000037988.07114.98
Keywords
vascular endothelial growth factor (VEGF); hypoxia; hippocampal neurons; N-miethyl-D-aspartate (NMDA); excitotoxicity; caspases
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The authors investigated the effect of vascular endothelial growth factor (VEGF) on hypoxic injury of cultured rat hippocampal neurons. Treatment with glutamate receptor antagonists prevented hypoxic neuron death. The same magnitude of protection was observed in Cultures treated with VEGF, which also reduced excitotoxic neuron death induced directly by an exposure to N-methyl-D-aspartate. Vascular endothelial growth factor did not alter the activation of the transcription factor nuclear factor-kappaB during hypoxia and protected cells in a PI-3-kinase-independent manner. Vascular endothelial growth factor failed to protect against staurosporine-induced, caspase-de pendent apoptosis. These data suggest that VEGF-induced protection against hypoxic injury primarily involves the inhibition of excitotoxic processes.
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