Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 6, Issue 5, Pages 619-629Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1367-5931(02)00380-0
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The three-dimensional structure of glycosidases and of their complexes and the study of transition-state mimics reveal structural details that correlate with mechanism, Of particular interest are the transition-state conformations harnessed by individual enzymes and the substrate distortion observed in enzyme-ligand complexes. 3D-structure in synergy with transition-state mimicry opens the way for mechanistic interpretation of enzyme inhibition and for the development of therapeutic agents.
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