Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 19, Issue 10, Pages 1760-1768Publisher
OXFORD UNIV PRESS
DOI: 10.1093/oxfordjournals.molbev.a003998
Keywords
protein interaction networks; microarrays; gene knockout; biochemical innovation
Funding
- NIGMS NIH HHS [GM63882] Funding Source: Medline
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Most duplicate genes are eliminated from a genome shortly after duplication, but those that remain are an important source of biochemical diversity. Here, I present evidence from genome-scale protein-protein interaction data, microarray expression data, and large-scale gene knockout data that this diversification is often asymmetrical: one duplicate usually shows significantly more molecular or genetic interactions than the other. I propose a model that can explain this divergence pattern if asymmetrically diverging duplicate gene pairs show increased robustness to deleterious mutations.
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