Journal
PLANTA MEDICA
Volume 68, Issue 10, Pages 934-936Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2002-34936
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Using the guidance by a competitive assay for the benzodiazepine binding site in the GABA(A) receptor, active compounds were isolated from the rhizomes and roots of Valeriana wallichii DC. The UV, NMR and mass spectral data permitted the identification of 6-methylapigenin. This flavonoid has a Ki = 495 nM for the BDZ-bs and a GABA ratio of 1.6-2.0, which suggests possible agonistic properties. The calculated percentage of 6-methylapigenin in the crude drug is in the range: 0.013 % to 0.0013 %.
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