Journal
IMMUNITY
Volume 17, Issue 4, Pages 501-514Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(02)00426-0
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Funding
- NIAID NIH HHS [R01 AI 46225] Funding Source: Medline
- NIAMS NIH HHS [P30 AR48311] Funding Source: Medline
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The physiologic role of eight CD19 tyrosines was examined in CD19-knockout mice expressing transgenic CD19 constructs. CD19 Y482 and Y513 were essential for normal B cell biology, including differentiation of 131 and marginal zone B cells and for T-dependent and -independent antibody responses. In immunized mice with mutations in CD19 Y482 and Y513, early germinal center B cells appeared normal in phenotype and number, but maturation in the germinal center was defective. This was associated with retarded progression through the cell cycle. Thus, Y482 and Y513 are essential for all functions of CD19 in vivo. Mutation of these reduces proliferation in germinal center B cells, providing a potential mechanism for the failure of maturation, which abrogates antibody responses.
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