Journal
SYNLETT
Volume -, Issue 10, Pages 1625-1628Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2002-34241
Keywords
catalysis; amino acids; aldol reaction; Lewis acid
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The combination of triethylamine, magnesium(II) perchlorate and bipyridine generates a catalyst system for the efficient combination of ethyl isothiocyanatoacetate and a range of aromatic aldehydes. The products of these reactions are synthetically valuable protected beta-hydroxy alpha-amino acids.
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