Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 37, Issue 10, Pages 783-791Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(02)01347-8
Keywords
phosphomarman; phosphosulfomannan; anticoagulant; capillary electrophoresis; PI-88
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Funding
- NHLBI NIH HHS [HL 52622] Funding Source: Medline
- NIGMS NIH HHS [GM 38060] Funding Source: Medline
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A yeast-derived phosphomannan mixture was chemically sulfonated and the composition and structure of the product mixture was studied. This phosphosulfomannan mixture, PI-88, is currently under clinical evaluation as an anti-cancer agent. Analysis using capillary electrophoresis demonstrated that PI-88 was a multi-component mixture. Gel permeation chromatography provided four fractions of PI-88 that contained components which differed in size from disaccharide to hexasaccharide, and by degree of sulfation. These fractions were characterised by spectroscopic and chromatographic methods and the structure of PI-88 is that expected based On the structure of the phosphomannan starting material. The anticoagulant activity of these fractions was evaluated and the structural requirements for,activity are described. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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