Journal
DEVELOPMENTAL CELL
Volume 3, Issue 4, Pages 557-568Publisher
CELL PRESS
DOI: 10.1016/S1534-5807(02)00270-8
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Funding
- NICHD NIH HHS [R01HD37277-04] Funding Source: Medline
- NIDDK NIH HHS [T32DK07191] Funding Source: Medline
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To identify a regulatory role for proteolysis during early Xenopus development, we developed a biochemical screen for proteins that are degraded in an embryonic stage-specific manner. We found that Xom, a homeobox transcriptional repressor of dorsal-specific genes, was degraded precipitously during early gastrulation. Xom degradation is regulated by phosphorylation at a GSK3-like consensus site and is most likely mediated by the SCF-beta-TRCP complex. Expression of nondegradable Xom represses transcription of dorsal genes much more effectively than wild-type Xom and results in a more strongly ventralized phenotype. We propose that regulated Xom proteolysis plays an essential role in the establishment of the dorsoventral axis, by converting a gradient in BMP abundance into a sharp dorsoventral pattern.
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