Journal
CURRENT ORGANIC CHEMISTRY
Volume 6, Issue 12, Pages 1057-1096Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272023373635
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This review deals with recent progress in the synthesis of fluorine-containing heterocyclic compounds using the fluorinated building block method. Several fundamental fluorinated building blocks such as fluorine-containing multiple bond compounds, fluoroalkyl substituted carbonyl compounds are described in detail, they are readily prepared and easy to scale up from the commercial available starting materials such as RfX, R(f)CXYZ (X, Y, Z: halogen), (CF3CO)(2)O etc. Under mild reaction condition, they react with various organic reagents to give a variety fluoroalkyl substituted N, S, O-heterocycles.
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