Journal
MECHANISMS OF DEVELOPMENT
Volume 118, Issue 1-2, Pages 147-155Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(02)00240-X
Keywords
mouse; endoderm; liver; pancreas; prox1; Hnf6; Hnf3 beta; Bmp4; Hex; Shh; Pdx1
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Funding
- NCI NIH HHS [CA21765] Funding Source: Medline
- NEI NIH HHS [EY12162] Funding Source: Medline
- NIGMS NIH HHS [GM58462] Funding Source: Medline
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Although important progress has been made recently in the elucidation of the molecular mechanisms that regulate differentiation and morphogenesis of endoderm-derived tissues such as pancreas and liver, less is known about the preliminary steps of early regional specification. Recent evidence supports the proposal that the early endoderm contains a bipotential precursor cell type for pancreas and liver. We have also previously shown that the activity of the homeobox gene Prox1 controls hepatocyte migration during liver morphogenesis. Using detailed comparative analysis of whole embryos and reverse trzmscriptase polymerase chain reaction of dissected embryonic endoderm, we have now determined that in the early endoderm, Prox1 expression is restricted to regions giving rise to the mammalian pancreas and liver. This finding indicates that Prox1 is one of the earliest specific markers of this commonly fated region of the mammalian endoderm. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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