Journal
VACCINE
Volume 20, Issue 29-30, Pages 3560-3568Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(02)00334-1
Keywords
tick vaccine; secreted antigen; concealed antigens; Rhipicephalus appendiculatus
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Blood-feeding ectoparasites, such as mosquitoes, sandflies and ticks, transmit many disease agents. Their control relies on large-scale, repeated use of chemical pesticides. An alternative, targeted and environmentally friendly approach is to develop anti-ectoparasite vaccines. We describe a vaccine to control ticks that targets an 'exposed' tick saliva antigen and cross-reacts with 'concealed' tick midgut antigens. Ticks feeding on immunised animals induced a cutaneous inflammatory response and increased antibody titer, while engorged ticks died following damage to their midgut. This dual action, acting at the feeding site and in the midgut, offers a self-sustaining strategy for ectoparasite control boosted by natural infestations. (C) 2002 Elsevier Science Ltd. All rights reserved.
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