Synthesis and mannose receptor-mediated uptake of clustered glycomimetics by human dendritic cells: Effect of charge

Effect of charge and shape of multivalent lysine-based cluster glycomimetics on their mannose receptor-mediated uptake by human dendritic cells has been evaluated: The capture is strongly affected by the shape of the ligands. The effect of charge is less pronounced although positive charges on the ligands seem to favor non-specific endocytosis capture. (C) 2002 Elsevier Science Ltd. All rights reserved.