Journal
CANCER LETTERS
Volume 184, Issue 1, Pages 97-104Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(02)00187-8
Keywords
hepatitis B virus; hepatitis B virus X; NF-kappa B; proliferation; apoptosis
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In this paper, we examined the cellular effect of hepatitits B virus X (HBx) in ChangX-34 cells, inducible HBx-expressing cells. High expression of HBx protein in ChangX-34 cells resulted in approximately three-fold increase in DNA synthesis and did not show apoptotic changes. Expression of HBx in these cells was accompanied by the NF-kappaB-mediated transcription. Interestingly, inhibition of NF-kappaB activity either by treatment with sulfasalazine, a specific inhibitor of NF-kappaB, or by expressing IkappaBalpha super-repressor significantly increased cell death in ChangX-34 cells but had no influence on parental Chang cells. Thus, the activation of NF-kappaB in HBx-expressing cells may play a critical role in shifting the balance toward cell survival. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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