Journal
FEBS LETTERS
Volume 529, Issue 2-3, Pages 319-324Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)03360-4
Keywords
mitotic kinase; WARTS; LATS1; centrosome; Cdc2; cyclin B
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Identification of physiological substrates for Cdc2/ cyclin B is crucial for understanding the functional link between mitotic events and Cdc2/cyclin B activation. A human homologue of the Drosophila warts tumor suppressor, termed WARTS, is a serine/threonine kinase and a dynamic component of the mitotic apparatus. We have found that Cdc2/cyclin B forms a complex with a fraction of WARTS in the centrosome and phosphorylates the Ser613 site of WARTS during mitosis. Immunocytochemical analysis has shown that the S613-phosphorylated WARTS appears in the spindle poles at prometaphase and disappears at telophase. Our findings suggest that Cdc/cyclin B regulates functions of WARTS on the mitotic apparatus. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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