Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 246, Issue 1-2, Pages 37-45Publisher
ELSEVIER
DOI: 10.1016/S0378-5173(02)00356-3
Keywords
nanoparticles; sunscreen agent; 2-ethylhexyl-p-methoxycinnamate; photodegradation; poly(lactide-co-glycolide); ethylcellulose
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The aim of this study was to investigate the influence of nanoparticle-based systems on the light-induced decomposition of the sunscreen agent, trans-2-ethylhexyl-p-methoxycinnamate (trans-EHMC). Ethylcellulose (EC) and poly-D,L-lactide-co-glycolide (PLGA) were used as biocompatible polymers for the preparation of the particulate systems. The salting out method was used for nanoparticle preparation and several variables were evaluated in order to optimize product characteristics. The photodegradation of the sunscreen agent in emulsion vehicles was reduced by encapsulation into the PLGA nanoparticles (the extent of degradation was 35.3% for the sunscreen-loaded nanoparticles compared to 52.3% for free trans-EHMC) whereas the EC nanoparticle system had no significant effect. Therefore, PLGA nanoparticles loaded with trans-EHMC improve the photostability of the sunscreen agent. (C) 2002 Elsevier Science B.V. All rights reserved.
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